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Insertional mutagenesis


  • URI(s)

  • Instance Of

  • Scheme Membership(s)

  • Collection Membership(s)

  • Variants

    • Activation, Insertional
    • Cassette mutagenesis
    • Gene insertion
    • Insertion, Gene
    • Insertion, Sequence
    • Insertion mutation
    • Insertional activation
    • Linker-insertion mutagenesis
    • Mutation, Insertion
    • Sequence insertion
    • Viral insertional mutagenesis
  • Broader Terms

  • Related Terms

  • Closely Matching Concepts from Other Schemes

  • Sources

    • found: Work cat: Insertional mutagenesis strategies in cancer genetics, 2011.
    • found: MESH browser, Aug. 26, 2016(Mutagenesis, Insertional -- Mutagenesis where the mutation is caused by the introduction of foreign DNA sequences into a gene or extragenic sequence. This may occur spontaneously in vivo or be experimentally induced in vivo or in vitro. Proviral DNA insertions into or adjacent to a cellular proto-oncogene can interrupt genetic translation of the coding sequences or interfere with recognition of regulatory elements and cause unregulated expression of the proto-oncogene resulting in tumor formation) [MESH UFs: Gene insertion; Insertion mutation; Insertional activation; Linker-insertion mutagenesis; Cassette mutagenesis; Sequence insertion; Viral insertional mutagenesis)
    • found: The plant cell, Dec. 1999:p. 2283 (Insertional mutagenesis is an alternative means of disrupting gene function and is based on the insertion of foreign DNA into the gene of interest)
    • found: American Heritage medical dictionary, 2007(Insertional mutagenesis -- Mutation caused by the insertion of new genetic material into a normal gene)
    • found: Developmental dynamics, Nov. 2003:p. 523 (Insertional mutagenesis is a method for identifying genes essential for a given biological process by using the integration of DNA as the mutagen, thereby facilitating the cloning of the mutated gene. ... [T]he cloning of chemically mutated genes is quite laborious. ... Insertional mutagenesis provides an alternative whereby the identification of the mutated gene is greatly facilitated by the presence of a molecular tag at the site of the mutagenic lesion. The sequence of the genomic DNA flanking the inserted element can be easily cloned and sequenced; thus, the beginning of the search for the mutated gene is greatly simplified)
  • LC Classification

    • QH463.13.I57
  • Change Notes

    • 2016-08-26: new
    • 2016-11-09: revised
  • Alternate Formats

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