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Gene drives


  • Here are entered works on naturally-occurring or engineered mechanisms by which a preferred version of a gene is passed down to successive generations, eventually becoming dominant in a population.

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  • Variants

    • Gene drive systems
    • Gene drive technology
  • Broader Terms

  • Closely Matching Concepts from Other Schemes

  • Sources

    • found: Work cat: National Academies of Sciences, Engineering, and Medicine (U.S.). Gene drives on the Horizon, 2016 :Publisher's description ("Research on gene drive systems is rapidly advancing. Many proposed applications of gene drive research aim to solve environmental and public health challenges, including the reduction of poverty and the burden of vector-borne diseases, such as malaria and dengue, which disproportionately impact low and middle income countries.")
    • found: Nature Reviews Genetics, February 15, 2016, viewed online January 18, 2018 :Cheating evolution, p. 146 (Abstract: "Engineered gene drives -- the process of stimulating the biased inheritance of specific genes -- have the potential to enable the spread of desirable genes throughout wild populations or to suppress harmful species, and may be particularly useful for the control of vector-borne diseases such as malaria. Although several types of selfish genetic elements exist in nature, few have been successfully engineered in the laboratory thus far. With the discovery of RNA-guided CRISPR-Cas9 nucleases, which can be utilized to create, streamline and improve synthetic gene drives, this is rapidly changing.")
    • found: FAQ: Gene drives (Undated press release from Wyss Institute, Harvard University), viewed online January 18, 2018 :What is a gene drive? ("During normal sexual reproduction, each of the two versions of a given gene has a 50 percent chance of being inherited by a particular offspring. Gene drives are genetic systems that circumvent these traditional rules: they greatly increase the odds that the drive will be passed on to offspring. This can allow them to spread to all members of a population even if they reduce the chance that each individual organism will reproduce...Almost every sexually reproducing species has either an active gene drive or the broken remnants of one in its genome.")
    • found: MeSH, viewed June 8, 2018(Gene drive technology: scope note: The techniques involved in creating and inserting synthetic selfish genetic elements called gene drives. Gene drives carry a "payload gene" and are designed to increase in frequency in the population over time, eventually to all members of the population. MeSH tree: Gene drive technology under Directed molecular evolution under Genetic engineering)
  • General Notes

    • Here are entered works on naturally-occurring or engineered mechanisms by which a preferred version of a gene is passed down to successive generations, eventually becoming dominant in a population.
  • Change Notes

    • 2018-01-18: new
    • 2018-07-13: revised
  • Alternate Formats

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