EDDP (Pyrrolidine derivative)

found: Work cat: Baugh, L.D. Gas chromatography/mass spectrometry analysis of methadone and EDDP in urine, [1989]:leaf 1 (The purpose of this study was to develop a method for the simultaneous determination of methadone and one of its major metabolites, 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), in urine specimens)

found: Drug metabolism and disposition, July 2015:page 994 (Differences in methadone metabolism by CYP2B6 variants . ... Methadone is a long-acting opioid with considerable unexplained interindividual variability in clearance. Cytochrome P450 2B6 (CYP2B6) mediates clinical methadone clearance and metabolic inactivation via N-demethylation to 2-ethyl-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP))

found: Clinical medicine & research, Dec. 2009:page 134 (Quantification of a methadone metabolite (EDDP) in urine: assessment of compliance. ... Objective: To investigate the possibility of utilizing the ratio of the methadone metabolite, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP), to urine creatinine to develop a regression model that would predict drug adherence in patients prescribed methadone for either pain management or drug addiction)

found: Progress in chemical toxicology, v. 5, 1974:page 33 (2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine and 2-ethyl-5-methyl-3,3-diphenyl-1-pyrroline were identified as metabolites of methadone in man and rat. The major metabolite eliminated by the rat was the pyrrolidine derivative)

found: Journal of clinical laboratory analysis, Mar. 2014:page 137 (Nine methadone urinary metabolites have been identified; however, 2-ethylidene-1,5-dimethyl-3,3-diphenylpyrrolidine (EDDP) is formed by N-demethylation and spontaneous cyclization of the primary urinary metabolite. EDDP is physiologically inactive. Urinary excretion of methadone plus EDDP may account for up to 57% of an administer[ed] dose. Continuous administration causes an induction of methadone metabolism resulting in increasing urinary EDDP)