The Library of Congress > Linked Data Service > LC Subject Headings (LCSH)

Alpha-synuclein


  • URI(s)

  • Variants

    • Alpha-syn
    • aSyn (Alpha-synuclein)
  • Broader Terms

  • Closely Matching Concepts from Other Schemes

  • Sources

    • found: Work cat.: Mangieri, L.R. Regulation of alpha synuclein accumulation by the autophagy lysosome pathway in a preclinical model of Parkinson disease, 2012.
    • found: The FASEB journal, Apr. 2004:p. 617 (Alpha-synuclein ([alpha]-syn) is a small soluble protein expressed primarily at presynaptic terminals in the central nervous system. Interest in [alpha]-syn has increased dramatically after the discovery of a relationship between its dysfunction and several neurodegenerative diseases, including Parkinson's disease (PD). The physiological functions of [alpha]-syn remain to be fully defined, although recent data suggest a role in regulating membrane stability and neuronal plasticity)
    • found: Annals of neurology, Oct. 2012:p. 517 (Parkinson disease (PD) is a common neurodegenerative disorder, second in frequency only to Alzheimer disease. PD can cause cognitive impairment as well as movement disorders. [alpha]-Synuclein is the major component of Lewy bodies and Lewy neurites, the filamentous inclusions characteristic of PD and other synucleinopathies such as dementia with Lewy bodies and multiple system atrophy. Besides being diagnostic of this group of diseases, the accumulation of aggregated proteins including [alpha]-synuclein is thought to play a role in neurodegeneration. [alpha]-Synuclein is a 140-amino acid protein that adopts an [alpha]-helical structure when bound to membranes but can also fold into a [Beta]-sheet--rich structure that polymerizes into fibrils and protein aggregates. It has been hypothesized that aggregated [alpha]-synuclein might behave like a prion, being capable of initiating misfolding and aggregation of nascent or even properly folded [alpha]-synuclein)
    • found: Cell death and disease, via WWW, July 18, 2013:archive/2012, July/July 19, 2012/Alpha-synuclein: from secretion to dysfunction and death/p. [1] (Alpha-synuclein (aSyn) is a 140 amino-acid protein that was originally identified in association with synaptic vesicles in the presynaptic nerve terminal and has been shown to interact with membranes both in vitro and in vivo. It is highly abundant in the brain and also present in other tissues, including red blood cells. aSyn is a member of a protein family of synucleins, together with beta- ... and gamma- ... synuclein. ... Point mutations in the SNCA gene, encoding for aSyn, and multiplications of the SNCA locus have been identified in families with autosomal-dominant forms of Parkinson's disease (PD))
    • found: MedicineNet.com, July 18, 2013(Alpha-synuclein: One in a family of structurally related proteins that are prominently expressed in the central nervous system. Aggregated alpha-synuclein proteins form brain lesions that are hallmarks of some neurodegenerative diseases (synucleinopathies). The gene for alpha-synuclein, which is called SNCA, is on chromosome 4q21. Defects in this protein are believed to be related to the development of Parkinson disease)
  • LC Classification

    • QP552.A4397
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  • Change Notes

    • 2013-07-01: new
    • 2013-09-26: revised
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