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Bibframe Work

Title
Histamine and Histamine Receptors in Health and Disease
Type
Text
Monograph
Multimedia
Language
English
Classification
DDC: 615 full (Source: 23)
Content
text
Summary
This book provides a comprehensive overview on current histamine and histamine receptor research in context of human health and disease and reflect the multidisciplinary nature of the field. While the editors realize that it is almost impossible to cover the field completely within the constraints of a single HEP volume, nonetheless, all important aspects will be covered in one way or the other. An overarching introductory chapter will link the individual chapters and provide an overview on the field. This chapter will also link the book to the previous HEP volume on histamine receptors and the recent HEP volume on the pharmacology of itch. Great attention will be paid to complementation of existing literature while avoiding undue duplication. The book will cover new methods for analysis of histamine and histamine metabolites, development of methods for histamine receptor analysis, signal transduction, histamine release, regulation of immune cells by histamine, histamine metabolism and associated diseases, regulation of major organ systems by histamine and development of new drugs and experimental tools for the study of histamine receptors.
Table Of Contents
Part 1: New Analytical tools
Histamine and histamine receptors: State of the art
Mass-spectrometric methods for the detection of histamine and histamine metabolites
Fluorescent ligands and radioligands for the analysis of histamine receptors
Molecular analysis of histamine receptors: Structural analysis of the histamine H1-receptor
Molecular modelling approaches for the analysis of histamine receptors
Cellular analysis of histamine receptors: Histamine release from human mast cells and basophils
Histamine H2-receptor in blood cells: A suitable target for the treatment of acute myeloid leukemia
Histamine H1-receptor-regulated gene expression and drug action of antihistamines
Histamine metabolism and transport: Analysis of the role of histamine and genetically engineered mice in a human disease model
Histamine clearance through polyspecific transporters in the brain
Histamine decarboxylase deficiency as a cause for Tourette syndrome
Histamine food poisoning
Integrative role of histamine in major organ systems: Pharmacological implications: Regulation of the cardiovascular system by histamine
Regulation of eating behavior by histamine
Role of the histamine H3-receptor in the CNS
Role of the histamine H4-receptor in bronchial asthma
The histamine H4-receptor in pruritic skin disease
Histamine in allergy and antihistamines.
Authorized Access Point
Histamine and Histamine Receptors in Health and Disease