Bibframe Work

This thesis describes the use of biophysical and biochemical methods to prove that calcium has a positive feedback effect on amplifying and sustaining CD3 phosphorylation and should enhance T-cell sensitivity to foreign antigens. The study presented shows that calcium can regulate the signal pathway in cells not only as a secondary messenger but also through direct interactions with the phospholipid bilayer. The approach used in the thesis also represents an important advance, as it couples the use of nuclear magnetic resonance (NMR) to the analysis of signaling phenomena in living cells. Moreover, the thesis optimizes the Nanodisc assembly protocol, which can broaden its range of applications in membrane protein studies. A preliminary study on the structure of dengue virus NS2B-NS3p in complex with aprotinin, which may help to develop new drugs against the dengue virus, is also included.

Table Of Contents

Introduction

Review

Nanodisc assembly and the study on the interaction between the lipid and ion

Calcium regulates T cell receptor activation through phospholipid electrostatic manipulation

The preliminary study on the structure of Dengue Virus NS2B-NS3p in complex with aprotinin

Summary and prospect of this dissertation.

Authorized Access Point

Bi, Yunchen Study of the Calcium Regulation Mechanism of TCR Activation Using Nanodisc and NMR Technologies

Admin Metadata

Generation Process: DLC marc2bibframe2 v2.5.0

Status: changed

Encoding Level: preliminary

Description Conventions: ISBD: International standard bibliographic descriptionProvider-neutral e-resource MARC record guidelinesResource description and access

Identified By: bf:Local, 21771623

Change Date: 2020-10-26T17:31:34

Creation Date: 2017-06-20

Description Language: English

Assigner: United States, Library of Congress

Bibframe Work

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